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Very approximately, therapeutic antioxidant strategies can be classified as (i) application of low molecular weight antioxidants and vitamins including activators of Nuclear factor erythroid 2–related factor 2 (Nrf2), playing an important role in the expression of antioxidant enzymes and (ii) targeting ROS with antioxidant enzymes involving SOD mimetics or NOX inhibitors (Batinic-Haberle et al