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Human trials limited: Clinical data shows modest or inconsistent results.³ Unclear mechanisms in humans: Translation from animals to people remains uncertain

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The frequency of MTHFR homozygous genotype 677CC was 89% in the vitamin B-12 group and 85% in the placebo group ( P = 0.18), and the frequency of homozygous 677TT was 0.6% in both groups ( P = 1.00)

but a deficiency may occur in certain health conditions (e.g.