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But it also means that the protocol as a whole has almost never been studied, and the evidence for each individual component varies from moderate to essentially nonexistent

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23 Furthermore, research dividing participants into low or high TMAO producers according to their response to TMAO precursors as supplements 27 or dietary sources 24 also supported that the gut microbiota differed between groups and that high TMAO producers had more Firmicutes than Bacteroidetes