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In addition, gastric acid and digestive enzymes can destroy glutathione, leading to its premature breakdown during digestion and limiting its bioavailability

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Furthermore, the involvement of AMP-activated protein kinase (AMPK) and hypoxia-inducible factors (HIFs) in the pathogenesis and progression of OA, as well as their close association with ferroptosis and mitophagy, should also be considered (Lu et al., 2021