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Among the identified 17 input non-synonymous SNP data-set, 4 nsSNPs (V289A, R233C, A199Tand R153C) were found to be “damaging” with score ranging between 0.5–1.000 and 0.990–1.000 in protein structure and function by SIFT and PolyPhen 2 tools respectively and the remaining two nsSNPs were characterized as benign (Table 1)

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These structural differences explain why the two compounds are rarely positioned as direct competitors in research literature AOD-9604’s non-receptor-mediated, localized action and GLP-3 RT’s multi-receptor systemic action address different points in the fat metabolism pathway, which is why researchers increasingly study them in combination rather than in isolation