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For example, vitamin C (Vit.C) reduces the production of free radicals, maintains GSH homeostasis, and induces the expression of HO-1, which is critical in limiting cellular damage by maintaining redox homeostasis within the brain (Rice, 2000

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Stock solutions of ascorbate were prepared on the same day of experiment and buffered with NaHCO 3 (Fisher Scientific, PA, USA) to bring pH to approximately 7