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Among the interconnected signaling mediators, the NF-κB, HIF-1α signaling, notch, PI3K/Akt, TGF-β, NMDA/HGF/c-Met, Rho/Rho-associated protein kinase, mitogen-activated protein kinase/extracellular signal-regulated kinase, Janus kinase/signal transducers and activators of transcription, and nuclear factor erythroid 2-related factor 2 signaling pathways deserve further investigation

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Most toxicologic pathologists use a common grading scale such as marginal or minimal, slight, moderate, marked, and severe for inflammatory, necrotizing, or other degenerative and responsive lesions