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For researchers studying how these aging mechanisms interact, the Epitalon spray can be combined with compounds that address additional hallmarks: NAD+ spray for cellular energy and sirtuin activation (addressing mitochondrial dysfunction and nutrient sensing), MOTS-C spray for metabolic signaling (addressing deregulated nutrient sensing through AMPK), and GHK-Cu spray for tissue regeneration (addressing stem cell exhaustion and altered intercellular communication through gene expression modulation)

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Cochrane Database Syst Rev, CD003967 (2006)