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Its molecular structure was optimized through genetic engineering technology: an additional 13 amino acids were added to the N-terminus of natural IGF-1 (70 amino acids, molecular weight 7.4 kDa) to form a long-chain structure of 83 amino acids (molecular weight 9.11 kDa), and the third glutamic acid (Glu) was replaced with arginine (Arg), hence the name "R3"

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Triple negative breast cancer chemosensitivity and chemoresistance: current advances in biomarkers indentification

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