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Ruf, Rajagopal, Kadnur, and colleagues, publishing in Scientific Reports in 2022, described novel tricyclic small-molecule NNMT inhibitors designed for metabolic disorders, confirming that NNMT inhibition is an active pharmaceutical pipeline pursued by multiple academic and commercial groups — not solely a gray-market compound

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Systemically, because it involves copper, there is a theoretical risk of copper overload with prolonged, high-dose use without proper cycling