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CrossRef Association of Mixed Use of Electronic and Conventional Cigarettes and Exposure to Secondhand Smoke With Prediabetes Seung Hoon Kim, Minah Park, Gyu Ri Kim, Hye Jin Joo, Sung-In Jang The Journal of Clinical Endocrinology & Metabolism.2022

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Different studies have shown that the deposition of Aβ can occur from early age in persons with DS, but after age 30–40 yr Aβ deposition in brain is observed in nearly all DS individuals, and accumulation is exponential, meaning not only an early onset of the disease but also an acceleration in the deposition of Aβ plaques with age, compared with the general population (457)