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In vitro models In the past decade, human skin (fibroblast) and blood (monocyte) cells from patients with neurodevelopmental and psychiatric disorders [78, 79], including subjects with 22q11DS [52, 80] have been reprogrammed into induced pluripotent stem cells (iPSCs) that can be further differentiated into 2D brain cells or 3D organoids for in vitro study [81]

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Hsiao, D., Wu, H., Malhotra, N., Liu, C., Wu, H., Lin, N., Saputra, F., Santoso, F., & Chen, C

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