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Nrf2 can be phosphorylated by several kinases, such as PI3K, protein kinase C (PKC), c-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinases (ERKs), inducing its dissociation from Keap1 and its translocation to the nucleus [71]

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Also, BPC 157 counteracts chronic heart failure (Lovric Bencic et al., 2004) or venous occlusion (Vukojevic et al., 2018)–induced hypotension (Lovric Bencic et al., 2004