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Intrinsic factor is a protein needed so that B12 can be absorbed

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However, regardless of the type, excessive intake of both - P5P or pyridoxine - when not needed, may lead to nerve and/or spinal degeneration, so extra Vitamin B6 should be used with caution, or only by someone with an otherwise difficult-to-manage low magnesium / high calcium ratio, (see also " Calcium & Magnesium ") and " Mineral Ratios ")