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A variety of cellular stresses, including DNA damage can cause the induction of cellular senescence, which represents a multifaceted and highly heterogeneous cellular state characterized by irreversible growth arrest and importantly the secretion of a multitude of factors, including proteases and chemokines 2

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Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells