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KPV is the C-terminal tripeptide of alpha-MSH, and the reported activity is anti-inflammatory signalling interference rather than receptor blockade

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Subsequently, Fe 3+ taken up into the cell is reduced to Fe 2+ by STEAP3 metalloreductase in the endosome and is then released into the labile iron pool of the cytoplasm by divalent metal transporter 1 (DMT1) [55]