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According to the National Academies of Sciences, Engineering, and Medicine (NAP), a safe highest level is called the “tolerable upper intake level.” Assessment of what amount is too much is based on animal and human studies, published evidence of adverse events, and professional agreement based on a committee of experts

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Indeed, evidence suggests that peripheral innate immune system molecules can trigger a secondary neuroinflammatory response in the central nervous system (CNS) 8,9,10