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While free radicals are a natural part of the body’s functioning, an overabundance can lead to oxidative stress, resulting in cellular damage and contributing to various chronic diseases (Zakeri et al., 2021)

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On the other hand, TNFR2 signaling is associated with the formation of NETs, which are structures that can trap and kill microbes, and the generation of ROS via nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 activation, further amplifying the antimicrobial response [88]