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Ralph Carmel, l’un des scientifiques modernes ayant le plus étudié la B12, nous rapporte dans une de ses études : « La majorité des carences nouvellement identifiées sont de nature subclinique, avec un impact incertain sur la santé

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Functional and structural conservation between human G6PD and Leuconostoc mesenteroides G6PD points to three widely conserved regions on the enzyme: a nine-residue peptide in the substrate binding site, RIDHYLGKE (residues 198–206 on human G6PD), a nucleotide-binding fingerprint, GxxGDLA (residues 38–44 on human G6PD), and a partially conserved sequence EKPxG near the substrate binding site (residues 170–174 on human G6PD), where we have use "x" to denote a variable amino acid