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DSIP also modulates the hypothalamic‑pituitary‑adrenal (HPA) axis, lowering nighttime cortisol spikes and reducing stress‑related arousal, which contributes to more stable circadian rhythms Peptide therapy for sleep has an excellent safety profile when administered under qualified medical supervision, with minimal side effects and no dependency risk

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In addition, after 4 weeks, those who ate watermelon had: higher levels of antioxidants in their blood lower systolic blood pressure a lower body weight and body mass index (BMI) an improved waist-to-hip ratio However, this study had a small number of participants and the cookie contained twice as much sugar as the watermelon