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It remains important that correlative and mechanistic studies continue to unpick the complex immune response to coronaviruses to hone-in on which aspects of immunity are most effective against coronaviruses to inform vaccine design

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While some molecules are progressing (e.g., CIN-109 and as CIN-209 as a dual GLP-1RA), some trials have noted only modest effects on body weight and are no longer in the pipeline (e.g., LY3463251