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If you started conservatively at 250 mcg per day and progress has stalled at week 3, moving to 500 mcg is reasonable

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A number of satiety signals that are released from the intestine include cholecystokinin (CCK), pancreatic polypeptide (PP), peptide-YY (PYY), oxyntomodulin, enterostatin, and glucagon -like peptide-1 (GLP-1) [5-10]

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