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[DOI] [PMC free article] [PubMed] [Google Scholar] 238.Ilic S., Drmic D., Zarkovic K., Kolenc D., Brcic L., Radic B., Djuzel V., Blagaic A.B., Romic Z., Dzidic S., et al

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In the 1970s, Prescott and coworkers in the UK used an IV protocol [15], while Rumack and coworkers in the US developed a 72-hour oral treatment protocol because the US Food and Drug Administration did not approve the use of the mucolytic drug by the IV route [60]